Fevarin - very good ANTI DEPRESSANT
about fevarin
Fevarin
fluvoxamine maleate
Common data on a drug
Trade name:
Fevarin®
INN:
fluvoxamine maleate
The medicinal form:
Tablets fevarin 4 the intake, coated with a film casing, with scratch index on the one hand
In a drug it is not contained neither lactoses, nor Saccharum.
Pharmacokinetics
After intake Fevarin it is completely absorbed from a gastrointestinal tract. The maximum concentrations of a drug in a blood plasma are marked in 3-8 hours after injection fevarin. The mean effective half-life from the blood plasma, 13-15 hours amounting 4 a single dose, is a little increased at a multiple dose (17-22 hours), and equilibrium concentrations in a blood plasma (steady-state), as a rule, are attained in 10-14 days.
Indications
Treatment and prophylactics of depressive distresses. Treatment of symptoms compulsive distresses.
Contraindications
Fevarin or 2 one of the weighing materials which are a part of this drug, and also patients W the expressed violations of function of a liver is contraindicative to patients W known hypersensitivity 2 fluvoxamine maleate.
The drug should not be assigned to children till 8 years.
Application during pregnancy and in a milking period
The probes devoted to study of a reproduction for laboratory animals, receiving heavy rates Fevarin, drops of a fecundity, violations of a sexual behaviour and teratogenic effects for their offspring have not revealed. Nevertheless it is necessary to observe the ordinary precautions concerning application of NE medical products during pregnancy. Fevarin in small amounts inpours into breast milk. In this connection it cannot be applied in a milking period.
Precautions
For the patients, suffering affliction depression the probability of tryings of a suicide which one can be saved before reaching of sufficient remission, as a rule, is high.
Treatment of the patients, suffering affliction hepatic or renal unsufficiency, it is necessary to start from low doses Fevarin under a strict medical monitoring. In rare instances treatment Fevarin can result in to an enhancement of activity of ferments of the liver, more often escorted by appropriate clinical symptoms. In these cases method Fevarin should be excellent. Despite the fact that what in probes on laboratory animals fluvoxamine did not call convulsive activity, it is necessary to show caution at assignment of a drug by the patient W spasms in the anamnesis. Treatment Fevarin should be terminated in case of developing of an epileptic attack. The data received at treatment of elderly and young patients, bear to lack of clinically significant distinctions between daily doses normally applied for them. Nevertheless rise of doses of a drug for elderly patients always should be conducted more slowly and W larger caution.
Fevarin can result in to insignificant decrease of frequency of cordial cutting-downs (on 2-6 impacts in a minute).
In the absence of clinical experience Fevarin it is not recommended to apply to treatment of depressions for children.
There are reports on such anomalous intradermal extravasations, as an ecchymoma and the purple watched at application of selective inhibitors of return acquisition of a serotonin. It is necessary to show caution at assignment of these medical products, specially, if it is a question of the patients simultaneously accepting drugs, which one influence function of thrombocytes (for example, atypical antipsychotic tools and aspirin, nonsteroid antiinflammatory medical products), and also ABT patients with bleedings in the anamnesis.
As well as at application of other psychotropic drugs, during treatment Fevarin it is not recommended to consume alcohol.
Method of application and doses
Depressions
The recommended launching dose compounds 50 or 100 mg fevarin (it is single-pass, 2NITE). Gradual rise of a launching dose B4 effective dose level is recommended. The effective daily dose normally amounting 100 mg, is selected individually depending on response of the patient to treatment. The daily dose can reach 300 mg fevarin. Daily doses over 150 mg fevarin should be arranged on some methods.
According to official guidelines of the World Health Organization treatment by antidepressants should be continued at least within 6 months after treatment of a depressive episode.
4 prophylactics of backsets of depression it is recommended to accept on 100 mg Fevarin once a day.
Doses 4 children are higher 8 years and teenagers
The initial dose compounds 25 milligramme fevarin a day on one method. A maintenance dose - 50-200 mg/days. The daily dose should not exceed 200 milligramme fevarin. Daily doses from above are recommended to be arranged 100 milligramme fevarin on 2 or 3 methods.
At the Gud answer to a drug treatment can be proceeded with the help of individually fitted daily dose. If enriching is not attained through 10 weeks Treatments, флувоксамина it is necessary to cancel method. Till now it has not been organised systemic probes which one could display, treatment fluvoxamine how long can be conducted, however obsession compulsive distresses have chronic nature, therefore it is possible to consider expedient extension of treatment Fevarin® over 10 week. For the patients who have is Gud answered this drug. Matching of the minimum effective maintenance dose should implement W caution in individual order. Some clinicians recommend carrying out of accompanying psychotherapy for the patients who have is Gud answered pharmacotherapy.
Treatment of the patients, suffering affliction hepatic or renal unsufficiency, it is necessary to start from the least doses under a strict medical monitoring.
Tablets Fevarin should be accepted not chewing and washing down with a water small amount.
Side effects
Most often observable symptom bound to application Fevarin, - a nausea sometimes escorted by vomiting. This by-effect, as a rule, disappears in first 2 week Treatments.
Other by-effects watched at carrying out of controllable clinical trials more than for 1 % of patients and marked brake, than at application placebo:
From central excitatory system: drowsiness, vertigo, a headache, a sleeplessness, alert, psychomotor drive, sense of pavor, a tremor;
From a digestive tube: a constipation, an anorexia, a dispepsia, a diarrhoeia, offensive feels in epigastric range, dryness in a mouth, feel of discomfort;
From cutaneous coverings: a reinforced diaphoresis;
The other: an asthenia, palpitation, a tachycardia.
As well as at application of other selective inhibitors of return acquisition of a serotonin, the transitional hyponatremia ceasing after cancelling Fevarin was seldom watched. In some cases it could be conditioned by a syndrome of inadequate secretion of antidiuretic hormone. The majority of reports has been bound to treatment of patients of a senile age.
The augmentation or skew field degrowth can sometimes be watched.
In rare instances after sharp cancelling Fevarin® such symptoms, as a headache, a nausea, vertigo and sense of pavor were marked.
Some from mentioned above undesirable appearances can be symptoms of depression and are optionally called Fevarin®.
Overdosing
Symptoms
Gastrointestinal distresses concern to the most typical symptoms (a nausea, vomiting and a diarrhoeia), drowsiness and vertigo. Besides, there are reports on violations of cordial activity (a tachycardia, a bradycardia, an arterial hypotension), violations of function of a liver, spasms and EVN a clod.
Till now has acted over 300 reports on cases of deliberate overdosing Fevarin. The best registered dose Fevarin received by one patient, has compounded 10 000 mg; this patient has been cured as a result of purely symptomatic therapy. More severe complications were watched in cases of deliberate overdosing Fevarin against accompanying pharmacotherapy.
Treatment
Specific antidote does not exist. At an overdosing the gastric lavage which one should be conducted as early as possible after drug method, and also an expected treatment is recommended. The absorbite multiple dose besides, is recommended. The profound diuresis or a dialysis are introduced unjustified.
The extension form
The tablets coated with a film casing, with scratch index on the one hand, in the blisters which have been laid down in cardboard wrappers on 15 tablets (fluvoxamine maleate or on 15 tablets of 100 mg fluvoxamine maleate).
Storage conditions
In the dry place protected from a direct sunlight, at the temperature of not above 25 °С.
In inaccessible to children a place.
Effective life
3 years at the storage condition in intact original package.
The drug fevarin cannot be applied at the expiration of effective life.
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